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Diabetes 62 , 115123 (2013)
doi: 10.1186/s13048-021-00867-0 20 DengHChenYXingJZhangNXuL
GSH and SOD are protective enzymes against ROS
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Furthermore, cells in several types of cancers are characterized by significant enhancement of glutathione biosynthesis, and this metabolic vulnerability has been targeted to sensitize these cancer cells to ROS-induced drugs 63
Shee, K
In this context, the CS regulation at both the enzyme and the gene level plays a pivotal role in the metabolic flux modulation of tumors, and scientists can target them for therapeutic purposes
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