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Semaglutide isnt a quick fix
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A Phase 2 trial found IGF-1 levels plateaued at month 6 despite continued daily dosing, suggesting partial desensitization of the GH-IGF-1 axis under constant stimulation
Data were processed with the XDS program package 28
IGF-1 LR3 acts directly at the IGF-1 receptor, bypassing the GH axis entirely
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