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Biochem Pharmacol 229:116471 Kelly CA, Sipos JA (2024) Approach to the patient with thyroid nodules: considering GLP-1 receptor agonists
Here, we show that the acute weight lossindependent actions of semaglutide to lower BP are ablated in Glp1r VSM/ mice, identifying an essential role for the VSMC GLP-1R as the BP-lowering target for semaglutide
No severe or confirmed hypoglycaemic episodes were reported in the two trials and there were no clinically relevant observations related to vital signs, physical examination, electrocardiogram or laboratory safety parameters, except temporary asymptomatic increases in lipase levels in two subjects at follow-up in the dosing conditions trial (from 46 U/L at screening to 231 U/L at follow-up and from 59 U/L at screening to 378 U/L at follow-up [normal range 1360 U/L])
Additionally, diquattreated LT2MYC tumors showed a small but significant increase in TUNEL staining, a marker of cell death, as compared to salinetreated tumors
This will be followed by a Phase III trial