Trials show GLP-1s can produce a 5% to 18% reduction in body weight, but the pace slows over time as your metabolism adjusts in clinical studies
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In the context of clinical practice, it may be important to assess for symptoms of eating disorders/disordered eating behaviors, mood instability, and general psychosocial functioning as well as quality of life, social support, health behaviors, and readiness to change prior to the initiation of and throughout the course of GLP-1 treatment [30]
SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose
Instead, the shedding is often related to the rapid changes happening within the body