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Nevertheless, we argue that a cytodegeneration of the myelinating unit may be the most proximal event, which could be potentially driven by a protein misfolding mechanism like most other neurodegenerative disorders
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STAT1 activation promotes M1 polarisation, and in contrast, STAT3/6 activation by IL-4, IL-13, and IL-10 leads to increased M2 polarisation (30)
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Are they related to the medications effects on the brain, or are they the result of reduced food intake, dehydration, changes in blood sugar, electrolyte imbalances, or nutritional deficiencies? That distinction is important
It serves as cofactor for multiple essential enzymes
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