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Retatrutide is investigated as a unimolecular agonist that engages three complementary incretin and glucagon pathways simultaneously, with research interest in body composition, hepatic lipid metabolism, glycemic endpoints, and energy expenditure in obesity and metabolic disease models

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The evolution from 2023 to 20242025 represents a movement from precautionary cessation to continuation with risk mitigation, reflecting a more sophisticated understanding of risk-benefit profiles [47]

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