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Lancet 2009;374:1606-1616 Erratum in: Lancet 2010;375:984

What is extraordinary about the AOD-9604 is its ability to reduce abdominal fat stores

Injections should be administered on the same day each week

The trade-off is borne entirely by the patient: higher rates of severe nausea, increased early dropout, and greater likelihood of metabolic adaptation (the body down-regulating GLP-1 receptors in response to abrupt dose increases)

Insulin was the first human protein manufactured using the method, approved for use in the treatment of diabetes in 1982

The drug is not available for self-administration or home storage outside of clinical trials