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Stampfer et al, 1992) established the link between hyperhomocysteinemia and occlusive coronary artery (Arnesen et al, 1995

Because B12 is water-soluble, extra is excreted rather than stored long term

The medication works by mimicking the natural GLP-1 hormone, which plays multiple roles in glucose regulation and appetite control

Activating it alongside GLP-1 may amplify the metabolic response beyond what either hormone achieves alone

[2] [3] With long-term use of these medications, this gastric emptying effect often diminishes somewhat (tachyphylaxis), though other appetite-suppressing mechanisms remain effective

Ghrelin is the best example for this, as its more commonly known as the hunger hormone, it makes you want to eat and fuels your appetite