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It appears to restore or enhance T-lymphocyte function and normalize cytokine profiles, possibly by acting on the thymus glandan organ that undergoes involution with age
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1), which is further supported by unaltered mRNA levels of inflammatory genes TNF, IL-6 and IL-1 (supplementary Fig
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These effects promote insulin resistance and intra-portal hyperinsulinemia that increases hepatic GH sensitivity to maintain some degree of IGF-I secretion
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