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Decreased mRNA expression or protein levels for TGF1, TGFBR1 [41], SMAD3 [42], SMAD6 [43], and SMAD7 [41, 43] have been reported in more advanced stages of COPD or fibroblasts from COPD patients
Functional enrichment analysis Functional enrichment analysis was performed using DAVID 2008 or Gene Set Enrichment Analysis (GSEA) v2.0.7 [16, 18]
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Adding GHK-Cu, optimizing minoxidil, or introducing PRP treatments at this stage addresses different bottlenecks that PTD-DBM alone cannot overcome