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I do agree with you on forecasting elements, but typically the results arent as drastic because they dont require as many human lifestyle changes
At week four, their provider moves them to Ozempic 2 mg, and appetite suppression strengthens noticeably
The STEP-4 trial (Rubino et al., JAMA , 2021) studied this directly: patients who reached goal weight on 2.4 mg were randomized to continue 2.4 mg vs switch to placebo
Thompson R, Taddei T, Kaplan D, Rabiee A
Hormonal differences in appetite regulation could also play a role
In clinical trials for weight management, tirzepatide produced average weight loss of 20-25% of body weight, roughly double what semaglutide achieves at comparable endpoints
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