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Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide
mechanisms and outcomes in humans are not established
Sites with adequate subcutaneous tissue depth produce the least discomfort
The dosing is gradually increased over time to reduce the chance of gastrointestinal discomfort, which is common during early weeks of treatment
Since both diabetes and obesity are risk factors for PDAC, there is a potential role for the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) for PDAC risk reduction
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