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Endogenous tissue inhibitors of MMPs (TIMPs) play a crucial role in safeguarding the BBB from disruption after ischemia by regulating the activities of MMPs [198]
Water molecules in the ocean can circulate for three thousand years, while water may only spend 2-6 months in rivers and streams, and hours to days in living organisms
However, in studies of acute lung injury caused by LPS, H 2 O 2 mediates not only inflammatory damage, but also has anti-inflammatory effects on neutrophils (Zmijewski et al., 2009)
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