Elongate the duration of channel opening (whereas benzodiazepins increase the frequency of channel opening)
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Food & Drug Administration (FDA) has approved certain GLP-1 drugs for commercialization and use, including liraglutide (Victoza), semaglutide (Ozempic, Wegovy), and tirzepatide (Mounjaro, Zepbound)
Patients with severe gastroparesis, pancreatitis history, or medullary thyroid carcinoma family history should discuss microdose GLP-1 with providers to assess appropriateness before initiation
In a hypothyroid patient whose platelet aggregation is already blunted, the additive antiplatelet effect of clopidogrel could theoretically increase bleeding risk, even without a pharmacokinetic interaction
10.1016/j.lfs.2017.12.015 36 WendeA