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I.TurturroF.WelbourneT.2011Enhancing glutaminolysis in glutamine dependent breast cancer cells with TRO provides a therapeutic window for GDH inhibition by EGCG inducing massive cell death

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Preclinical (animal) data show stunning results: Oral bioavailability of 4.2% 9 higher than tirzepatide 30 higher than oral semaglutide 6 higher than oral retatrutide 57 greater drug exposure than oral retatrutide Half-life ~56 hours Stronger receptor activation than retatrutide in vitro Suggests potential for the first powerful oral triple agonistworth watching