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5 Translational perspectives 5.1 Preclinical models and biomarker development The preclinical models and biomarker development represent the cornerstone of translational research towards incorporation of natural supplements in breast cancer therapy by adding mechanistic insights, validating efficacy, predicting therapeutic response, relevance towards patients for personalized therapy as well as on addressing their safety and dosing issues (219)

The risk of insulin sensitivity changes increases with prolonged high-dose use

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The specific effects of SCFAs are mediated by several mechanisms, including selective activation of the G-protein-coupled receptors family (GPCR), free fatty-acid receptors (FFARs), or epigenetic effects

The different products had comparable compositions and quantities of the components, with ferulic acid (5878.1%) being the most common [46]

Safety also depends on identity, purity, concentration, manufacturing and storage, as unregulated products may contain contaminants, incorrect doses or different ingredients