Mitophagy, mitochondrial homeostasis, and cell fate
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(Hurley & Frier, 2025) For patients, this means the first question to ask of any provider offering peptide therapy isn't "do you offer peptides" but "how are you sourcing them and what is the current regulatory status of each compound you prescribe?" A provider still listing Category 2 compounds as standard menu offerings without discussing compounding compliance is telling you something important about their regulatory literacy
Nature 645, 712721 (2025)
Clean sourcing and good technique protect the process, while sound habits amplify the signal
It also provides a mechanistic rationale for the combined use of these medications to target multiple pathways along the gut-brain axis, particularly for patients who have not achieved their health goals with a single medication