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The LEADER trial [17] was the first with a long-acting agonist (liraglutide provides a varying but relevant 24-hour exposure)
These medications carry an FDA boxed warning about potential thyroid C-cell tumor risk based on animal studies
Provided a robust manufacturing protocol for scale-up
Enhanced mood
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That combined with slower digestion from GLP-1 medication, dehydration worsens constipation, nausea and overall digestive discomfort
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