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The 0.01 mg/kg dose that showed consistent effects in rats translates to approximately 0.0016 to 0.004 mg/kg in humans, which works out to roughly 0.112 to 0.28 mg for a 154-pound person

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The GRX1-roGFP2 constructs show localization in the nucleus because the fusion protein can diffuse through the nuclear pores (Meyer et al., 2007)

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They will not fold back into their active configuration