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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

In the case of thin, crepey skin with many small wrinkles, the skin lacks its youthful support of collagen - and that can be corrected with collagen-induction therapies (there are non-invasive, non-surgical, and surgical options - generally speaking there is a trade-off between less invasive procedures needing more treatment sessions to achieve the same result as a more invasive procedure within this category of treatment)

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While a shortage of vitamin B6 will limit these functions, supplements of this vitamin do not enhance them in well-nourished individuals