A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice
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10.1042/bst0311337 51
(PubMed) Orban T, Sosenko JM, Cuthbertson D, et al
The problem is that peripheral lipolysis alone, without addressing energy balance, appetite, or the upstream hormonal environment that drives fat accumulation, appears insufficient for meaningful clinical weight loss in humans
To test the involvement of NRF2, we bred the Gclc f/f mouse strain with the Nrf2 f/f mouse strain 57,58 and induced a liver-specific double deletion with the AAV-TBG-Cre virus (hereafter referred to as L-DKO) (Fig