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Animal models exposed to 5-Amino-1MQ demonstrate accelerated lipid metabolism and extensive white adipose tissue remodelling, driven by up-regulated SIRT1 activity

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In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected