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Some providers may periodically measure basic labs (like liver/kidney function or copper levels) during extended treatment, especially if higher doses are used

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12,26 Furthermore, the formation of NAPQI adducts contributes to oxidative stress, mitochondrial dysfunction, disrupted Ca 2+ homeostasis, necrotic cell death, centrilobular necrosis, and eventual liver failure (Figs

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This important mechanism is enzymatically regulated by kinases (which phosphorylate proteins) and phosphatases (which dephosphorylate proteins)