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This seems to be the case for exon III but not for exon II, as expression of this exon was also decreased in Lepr flox/flox;Emx1-Cre mice with normal body weight

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Beyond localized pulmonary pathology, COPD is now recognized as a complex systemic syndrome, frequently accompanied by cardiovascular diseases, metabolic abnormalities, and skeletal muscle dysfunction (Barnes, 2010)

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