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A large number of studies have concluded that the decreased intracellular pH of endosomes and lysosomes in tumor cells may assist in metastasis by activating proteases [42, 48]
They produce various MMPs, tissue inhibitor of metalloproteinases (TIMPs) and most of the proteins comprising the ECM, such as collagens, fibronectin and laminin (Kalluri and Zeisberg, 2006
doi: 10.1016/j.engappai.2024.109128 253
doi:10.1111/j.1468-1293.2011.00975.x
de la Lastra JMP, Wardell SJT, Pal T, de la Fuente-Nunez C, Pletzer D
Dietary supplement use and documentation in a breast cancer survivorship clinic
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