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GLP-1 based medicines (including newer combination therapies that activate GLP-1 plus other gut hormone receptors) are used for type 2 diabetes, heart disease, and weight management
careful dose titration with physician oversight minimizes discontinuation
Viscoelasticity of biofilms and their recalcitrance to mechanical and chemical challenges
NINA MOINI: Oh, OK
Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc
When it comes to reduction of weight-related issues like diabetes, heart disease risks and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), bariatric surgery far outpaces GLP-1s in reduction, and often removal, of these risks
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