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Outcome measures histological scoring and gross visual assessment are not functional outcomes
First, the 0.25mg starting dose is not a therapeutic dose
Injection site reactions occurred at rates dramatically higher than placebo
AKT can also phosphorylate other chromatin-modifying enzymes, such as the histone methyltransferase EZH2 (H3K27 methylation) and DNA methyltransferase DNMT1, resulting in changes in function of these enzymes [90, 91]
J Exp Bot 53:12831304 Pastori GM, Kiddle G, Antoniw J, Bernard S, Veljovic-Jovanovic S, Verrier PJ, Noctor G, Foyer CH (2003) Leaf vitamin C contents modulate plant defense transcripts and regulate genes that control development through hormone signaling
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