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It is deeply involved in the pathogenesis and progression of diseases across the gut-organ axis pulmonary diseases, including cardiovascular diseases (such as atherosclerosis, heart failure, and hypertension), renal diseases, neurodegenerative disorders, and metabolic diseases, including diabetes

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This designation is relatively rare, as most people presenting for an FASD evaluation are at least suspected to have had a prenatal alcohol exposure due to the presence of other key features of FASD

J Pineal Res (2010) 48(1):919