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The liver is responsible for detoxifying harmful substances and metabolizing drugs

There are no formal studies, only user reports, but there is a plausible mechanism

"Niacinamide works with your skin's natural chemistry to improve overall skin texture by rebuilding a lipid layer, minimizing the appearance of pores, and preventing UV damage and inflammation as an antioxidant," Seattle-based board-certified dermatologist Brandith Irwin, MD, told Allure

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Professional monitoring helps determine dosage and track response