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As a medication, it is used for its antioxidant properties to treat various conditions, including liver diseases, detoxification of heavy metals, and potentially for its skin-lightening effects

Nature 266:565567 Xu D, Trmulot L, Yang Z, Mhamdi A, Chtel-Innocenti G, Mathieu M, Espinasse C, Van Breusegem F, Vanacker H, Issakidis-Bourguet E, Noctor G (2025) Cytosolic monodehydroascorbate reductase 2 promotes oxidative stress signaling in Arabidopsis

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Diorio, C., Brisson, J., Berube, S

Abbreviations Akt: Protein kinase B CDKs: Cyclin-dependent kinases ERK: Extracellular-signal-regulated kinases IB: Inhibitor of NF-B IKK: IB kinase IGF: Insulin-like growth factor IL-1: Interleukin-1 IL-2: Interleukin-2 IL-6: Interleukin-6 JNK: C-Jun N-terminal kinases LPS: Lipopolysaccharides MAPK: Mitogen-activated protein kinase MREs: Metal-response elements MT: Metallothionein MTF-1: Metal-regulatory transcription factor 1 NF-B: Nuclear factor kappa B NK cells: Natural killer cells PI3K: Phosphatidylinositol 3-Kinase ROS: Reactive oxygen species SOD: Superoxide dismutase Sp1: Specificity protein 1 TNF-: Tumor necrosis factor-alpha TRAF2: TNF receptor-associated factor 2 ZnT1: Zinc transporter 1 ZnT2: Zinc transporter 2 ZnT3: Zinc transporter 3 ZnT4: Zinc transporter 4 References Sun XR, Xu S, Liu TJ, Wu JW, Yang J, Gao XJ

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