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5h and Supplementary Fig

While these modest increases were not associated with increased cardiovascular adverse events in the clinical trials conducted to date, the long-term clinical significance of these small heart rate changes remains under investigation

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Unlike naturally occurring alpha-MSH, which has a brief circulating half-life measured in minutes, MT-IIs cyclic lactam bridge confers substantial proteolytic stability, extending its biological activity and making it a valuable research tool for investigating melanocortin signaling in laboratory models

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