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Regulation in PPAR-, Insulin and p53-mediated signaling have been implicated in NAFLD development, whereas signatures of inflammatory signaling such as Toll-like receptor (TLR) and Nucleotide-binding, oligomerization domain (NOD) protein signaling pathways, in addition to pathways reflecting mitochondrial dysfunction characterize NASH (Figure 5) (Ryaboshapkina and Hammar, 2017)

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