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Local ice application typically lasts 15-20 minutes per session, limited to prevent tissue damage from prolonged cold exposure

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For a 5 mg vial, adding 2.5 mL of bacteriostatic water creates a concentration of 2 mg per mL, or 0.2 mg per 0.1 mL

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Note that these doses are specific to cyanocobalamin, the preferred supplemental form of vitamin B12, as there is insufficient evidence to support the efficacy of the other forms, like methylcobalamin