It shows that isoliquiritigenin can cause breast cancer cells to undergo autophagy and apoptosis through mTOR
The research above (Badenhorst, Finkley, Abdulghani, Carey/Pickart) all studied topical application
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La Colla A, Vasconsuelo A, Milanesi L, Pronsato L (2017) 17-Estradiol protects skeletal myoblasts from apoptosis through p53, Bcl-2, and FoxO families