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This is the biological equivalent of building more docking stations (PDA increases receptors) and then sending more ships to dock (CJC-1295/Ipamorelin increases growth hormone)
The oral daily dose far exceeds the vitamin requirement because the normal transporter protein-mediated absorption is absent, leaving only very inefficient intestinal passive absorption
The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize
The pathology onset, senescent cell burden and expression of p16INK4a and Arf decreased with calories restriction (established anti-aging regime for lifespan extension in pre-clinical and clinical setting)
ISBN 978-0-12-709859-3
In skeletal muscle, promotes stem cell proliferation, regeneration, and muscle fiber hypertrophy post-injury 1
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