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First, most data evaluating combined SGLT2 inhibitor and GLP-1 receptor agonist therapy derive from post hoc analyses, subgroup analyses, observational cohorts, or trials primarily designed for glycemic or cardiovascular outcomes rather than dedicated heart failure endpoints

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Nevertheless, healthcare providers should consider these factors when prescribing semaglutide, especially for patients with a history of gallbladder disease or other risk factors for gallstone formation

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Once opened, injectable forms of Semaglutide like Ozempic and Wegovy can be stored at room temperature, below 86F, for up to 56 days

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