In contrast, vertical and complex tears may occur in areas with limited blood flow, making surgical intervention more likely
Predicted physicochemical properties supported its hydrophobic character and oral bioavailability, suggesting it is a metabolically stable and BBB-permeable molecule [1]
10.1016/j.bmc.2004.11.038 77 HoS
Preclinical studies have also highlighted neuroprotective properties, with DSIP reducing oxidative damage in brain tissue and accelerating functional recovery in models of neurological injury
In total, nine treated patients had significantly reduced discomfort and improved tear volume production, even 28 days following treatment
The peptide activates transforming growth factor-beta (TGF-) signaling cascades, leading to enhanced collagen I and III synthesis through increased procollagen C-proteinase activity