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Additionally, individuals with long-standing diabetes may already have some degree of diabetic gastroparesis, which could be worsened by GLP-1 medications

Less common but serious effects include pancreatitis, allergic reactions, and low blood sugar when used with insulin or sulfonylureas

Vitamin deficiencies, DNA changes, and blood vessel damage harm the placenta, raising the risk of high blood pressure, preeclampsia, and other complications for mother and baby

2 The APA article notes that many patients discontinue treatment within a year because of side effects, cost, access issues, or other challenges, but this source does not establish mental distress as a uniform or primary reason across all patients

Intravenous infusion of GLP-1 with direct recording of renal sympathetic nerve activity (RSNA) Rats were anesthetized with urethane (0.75 g/kg, i.p.) and -chloralose (70 mg/kg, i.p.)

[7] This strict administration requirement is necessary because GLP-1 peptides are normally broken down in the digestive system