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The essential role of the gut microbiota in immune development is highlighted in GF mice, which exhibit significant reductions in immune cell populations, including macrophages, dendritic cells, neutrophils, T cells, and B cells, along with lower cytokine production [31, 32]

2013 Sep;14(5-6):397-405

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doi: 10.1177/1756283X13491798 68 KhalifILQuigleyEMMakarchukPAGolovenkoOVPodmarenkovaLFDzhanayevYA