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GLP-1, GIP, amylin, and PYY primarily reduce appetite through central pathways and delay gastric emptying
Furthermore, these drugs delay gastric emptying and appear to increase satiety due to direct activity on the hypothalamus and brain stem
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2021;13(9):e18080
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Participants were randomised to receive CagriSema, semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, or placebo, all once-weekly over 68 weeks
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