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18 With continued efforts in the development of newer antidiabetic agents, unimolecular GLP1R/GIPR dual agonists (twincretins) can provide added efficacy, especially among obese individuals with T2DM
In another study, 73 of 77 participants underwent repeat DaTSPECT imaging at 96 weeks, but no significant differences in striatal binding changes were observed between the exenatide and placebo groups across all regions analyzed [34]
More receptor targets equals more neurological modulation equals higher likelihood of skin sensitivity
The STEP 1 trial with 1,961 participants [1] documented that 74% of patients experienced at least one gastrointestinal side effect, with nausea affecting 44% and diarrhea occurring in 30%
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