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NNMT upregulation was documented to elevate homocysteine levels, activating pro-inflammatory and pro-oxidative cascades including TLR4-NF-B and STAT3-IL-1 signalling
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Cell-culture research has shown that reducing NNMT was associated with less lipid accumulation in fat cells, while increasing NNMT was associated with more suggesting NNMT contributes to adipocyte function rather than simply marking metabolic dysfunction
Its role as an NNMT inhibitor highlights effects on metabolic function, endurance, and healthy aging
