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A 2001 RCT by Nusgens and colleagues published in the Journal of Investigative Dermatology (N=33) used punch biopsy to demonstrate that topical vitamin C significantly increases mRNA levels of collagen I, collagen III, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the human dermis direct molecular evidence of collagen gene upregulation at the tissue level

Reported symptoms are similar to those of Ozempic and are likely correlated to changes in blood sugar

For payers and pharmacy benefit managers (PBMs), the data have direct implications for coverage policy design