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GLP-1 ((glucagon-like peptide-1) drugs such as semaglutide work by mimicking a natural hormone that signals the brain to feel full and slows down digestion, helping one eat less and lose weight more effectively

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Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes