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The depletion of ROS from adipose tissue in mice models of oxidative stress was associated with increased adipose tissue mass, lower ectopic fat deposition, and enhanced IS
Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)
Onset varies with age, baseline tissue health, and protocol consistency
It triggers a strong, clean pulse of GH without significantly affecting other hormones, particularly cortisol (the stress hormone) and prolactin
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