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This may, in part, explain why the neuroprotective strategies trialled to date that are directed at a single target have generally been unsuccessful at producing clear benefits (Supplementary Table 2)

Glutathione supplementation helps to delay the aging and degenerative processes, keeping the body healthy and youthful

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Glutathione synthetase deficiency An inborn error of the gamma-glutamyl cycle

In like manner, while caudatin presents anti-inflammatory and neuroprotective properties in Alzheimers disease models, translation to humans will be more complex and we ultimately need to consider whether there are ways caudatin can pass the selective permeability of the blood-brain barrier

Notably, c-Myc was also reported to transcriptionally increase the expression of high-affinity glutamine transporters, including ASCT2 ( SLC1A5 ) and SNAT5 ( SLC38A5 ) (Wise et al., 2008