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Manipulations of various receptors such as 5 type GABA A Rs and sodium channels have been shown to enhance cognition (356)

AAS exposure has been associated with prolongation of ventricular repolarisation, increased dispersion of action potential duration, and reduced heart-rate variability, all of which facilitate arrhythmogenesis (71)

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Pharmacological treatments are reserved for specific circumstances and limited to licensed medications with demonstrated efficacy and safety profiles, such as orlistat or semaglutide (NICE TA875)

The review comes as peptides move out of niche anti-aging clinics into the burgeoning wellness market, fueled by social media influencers, biohacking communities and endorsement from Health Secretary Robert F