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Next, we performed an ex vivo cell-based glucose-stimulated insulin secretion (GSIS) assay using primary pancreatic islet cells isolated from either WT mice or GLP-1R knock-out mice (Fig

This is then determined using a high-performance liquid chromatograph equipped with a diode array detector or ultraviolet detector, with quantification performed by the external standard method

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Unlike FDA-approved versions, compounded forms may not be subject to the same rigorous safety and efficacy testing

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Safety profile : Whilst lower doses might theoretically reduce the incidence of dose-dependent adverse effects such as nausea and vomiting, this has not been systematically studied, and the overall risk-benefit ratio remains unknown