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Free radicals are neutralized and other oxidants are reduced by the direct action of glutathione (GSH) and indirectly via enzyme glutathione peroxidase, which used glutathione (GSH) as a cofactor

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Ferroptosis deficiency in GPX4-overexpressing mice protects against renal interstitial fibrosis during UUO Using GPX4-overexpressing (GPX4-OE) mice, we investigated the role of TEC ferroptosis in the progression of renal interstitial fibrosis