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In a study conducted in obese male patients all exenatide responders, defined as those who consumed lower food calories by exenatide administration compared to placebo, exhibited significantly higher hypothalamic connectivity measured by food cue-paired fMRI compared with placebo injection [41]

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[4] evaluated the distribution of GLP-1R in human brains and demonstrated its presence in all neurons of the parietal cortex, in the ARC, PVN, VMN, area postrema, dorsal motor nucleus of the vagus in the medulla oblongata, and in the NTS

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But now, advocates fear these drugs may continue to be out of reach for many